Elsevier; 2021. https://www.clinicalkey.com. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. Isosorbide is in a class of medications called vasodilators. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. Some of these interactions can be life-threatening. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Isosorbide mononitrate helps to prevent angina chest pain from developing. 2005 - 2023 WebMD LLC. All rights reserved. 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. This makes it easier for your heart to pump, relieving heart-related chest pain. Don't drink alcohol while taking isosorbide mononitrate (Monoket). Higher dosages are associated with stomach irritation and Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide. Take isosorbide exactly as directed. Continue to take isosorbide even if you feel well. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Mayo Clinic. In Canada - Call your doctor for medical advice about side effects. It is not intended as medical advice for individual conditions or treatment. https://naturalmedicines.therapeuticresearch.com. . This content does not have an English version. Swallow the extended-release tablets or capsules whole; do not crush, chew, or divide them. These headaches may be a sign that the medication is working as it should. In: Current Medical Diagnosis & Treatment 2022. You can take your doses either before or after meals. Do not take a double dose to make up for a missed one. Meinertz T, Lehmacher W; Trapidil/ISDN Study Group. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. Murray MT. Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. You may report side effects to Health Canada at 1-866-234-2345. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Tachjian A, et al. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. Isosorbide may cause other side effects. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Natural Medicines. You can start a phase IV clinical trial to monitor Isosorbide mononitrate safety and effectiveness. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. You can consult me online for homeopathic treatment. Seek alternatives to the CYP3A4 substrate when possible. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. In the US - Call your doctor for medical advice about side effects. Do not stop taking isosorbide without talking to your doctor. privacy practices. from the best health experts in the business. St. John's wort. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Dated October 2016. Never give it to other people even if their condition appears to be the same as yours. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. Never take more than the prescribed dose. There are 195 drugs known to interact with Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. If concomitant therapy cannot be avoided, monitor clinical effects of the . I would rather take the chance of a heart attack than have no quality of life. If you notice any other effects, check with your healthcare professional. This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". Journal of the American College of Cardiology. In the remainder of them there was a highly significant time effect: the overall numbers of headache attacks in the first period of active treatment versus the second were 2,380 vs 1,400 (P < 0.003). Isosorbide mononitrate is very similar to isosorbide dinitrate. B complex. To use the sharing features on this page, please enable JavaScript. Side effects : headache, mild dizziness About one-half of adults in the United States say they have used one or more supplements in the past 30 days. tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. Isosorbide extended-release (long-acting) tablets and extended-release capsules are used for the management of chest pain in people who have coronary artery disease. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. This drug may make you dizzy. https://naturalmedicines.therapeuticresearch.com. It relaxes blood vessels in your body (causing them to widen) and this reduces the strain on your heart, making it easier for your heart to pump blood around your body. For instance, many herbal supplements that are used often interact with the blood thinner warfarin (Jantoven). 67% of reviewers reported a positive effect, while 13% reported a negative effect. Portions of this document last updated: Feb. 01, 2023. Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. This product is available in the following dosage forms: There is a problem with If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Limit alcoholic beverages. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Less commonAbnormal heart soundabsence of or decrease in body movementarm, back, or jaw painblack, tarry stoolsbladder painbleeding after defecationbleeding gumsblood in the urine or stoolsblurred visionbody aches or painburning while urinatingburning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingschest pain or discomfortchest tightness or heavinesschillscold sweatscoldsconfusionconvulsionscough or hoarsenessdecreased urinediarrheadifficult or labored breathingdifficult, burning, or painful urinationdilated neck veinsdizzinessdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positiondry mouthear congestionextra heartbeatsfaintingfast, slow, irregular, pounding, or racing heartbeat or pulsefever or chillsflu-like symptomsfrequent urge to urinatefrequent urinationgeneral feeling of discomfort or illnessheadacheheadache, severe and throbbingheart murmurincreased need to urinateincreased sweatingincreased thirstincreased volume of pale, dilute urineirregular breathingitching, pain, redness, or swelling on the legjoint pain, stiffness, or swellinglightheadednessloss of appetiteloss of voicelower back, side, or stomach painmuscle aches and painsmuscle crampsnasal congestionnausea or vomitingnervousnessnumbness or tingling in the hands, feet, or lipspain or discomfort in the arms, jaw, back, or neckpain, tension, and weakness upon walking that subsides during periods of restpartial or slight paralysispassing urine more oftenpinpoint red or purple spots on the skinpounding in the earsrunny noseshakiness in the legs, arms, hands, or feetshiveringsneezingsore on the legsore throatsudden decrease in the amount of urinesweatingswellingswelling of the face, fingers, feet, or lower legstightness in the chesttrembling or shaking of the hands or feettrouble sleepingtroubled breathinguncomfortable swelling around the anusunusual bleeding or bruisingunusual tiredness or weaknessvomiting of blood or material that looks like coffee groundsweaknessweight gainRareBluish-colored lips, fingernails, or palmsdark urinepale skinrapid heart rateGet emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdoseBlurred or loss of visionbulging soft spot on the head of an infantchange in consciousnesschange in the ability to see colors, especially blue or yellowcold, clammy skindisturbed color perceptiondouble visionfeeling of constant movement of self or surroundingshalos around lightsheadache, severe and throbbingloss of consciousnessnight blindnessoverbright appearance of lightsparalysissensation of spinningtunnel visionSome side effects may occur that usually do not need medical attention. Take care, thanks. Is not subject to the Controlled Substances Act. The authors assessed the occurrence of angina pectoris and headache by diary cards while taking into account the number of isosorbide dinitrate sublingual puffs and paracetamole tablets required. The extended-release capsule usually is taken once daily. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. We study 23,548 Isosorbide mononitrate users. Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. government site. Real test is coronary angiography. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks ( chest pain ). Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. May also be prescribed off label for Esophageal Spasm. AHFS Patient Medication Information. Isosorbide-5-mononitrate ISMN usually begins acting within 30 minutes and its effects last six to eight hours. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. This is not a complete list of possible side effects. Registered in England and Wales. Accessed Sept. 7, 2022. Available for Android and iOS devices. Does Alcohol Raise Your Blood Pressure? A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Hawthorn. WebMD does not provide medical advice, diagnosis or treatment. A randomized, double-blind, cross-over study. AskMayoExpert. Take your next dose at the regular time. Are you looking for information on isosorbide dinitrate (Isordil) instead? Properly discard this product when it is expired or no longer needed. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). It will not treat an angina attack that has already begun. Accessed Sept. 7, 2022. Make sure laboratory personnel and all your doctors know you use this drug. Background: This branded product is no longer on the market. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). Tolerance is more likely to happen if you don't take your dose at the same time every day. Talk to your doctor if you are using marijuana (cannabis). This medication belongs to a class of drugs known as. Methods: In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. https://naturalmedicines.therapeuticresearch.com. Isosorbide mononitrate dose 10 mg twice daily to 120 mg daily in divided doses. Drug information provided by: IBM Micromedex. Receive price alerts, news, and other messages from GoodRx about isosorbide mononitrate (Monoket) and other healthcare topics and relevant savings offers. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Would you like email updates of new search results? We don't support your browser. Call your doctor if you have any unusual problems while you are taking this medication. prevention of anginal chest pain associated with coronary artery disease, prevent bleeding varicose vein in the esophagus. In case of overdose, call the poison control helpline at 1-800-222-1222. Natural Medicines. Unless there is a specific reason you need the brand, the generic medication will be a better value. MBBS, MS - General Surgery, mch neuro surgery. HHS Vulnerability Disclosure, Help Do not take more or less of it or take it more often than prescribed by your doctor. Let your provider know if they are excessive. Of the total drug interactions, Browse Drugs and Medicines. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. View interaction reports for isosorbide mononitrate and the medicines listed below. Isosorbide mononitrate tablets and capsules are not suitable to take to treat the pain of an angina attack. What special dietary instructions should I follow? Profen and Metoclopramide drug interaction, Metoclopramide and Nitrostat drug interaction, Metoclopramide and Alfentanil drug interaction, Risperdal and Metoclopramide drug interaction. Longer-acting tablets and capsules are taken once daily in the morning. health information, we will treat all of that information as protected health If you notice other effects not listed above, contact your doctor or pharmacist. Isosorbide mononitrate belongs to the group of medicines called nitrates. Some of these medicine interactions can be risky. Nitroglycerin has an average rating of Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. The information on this page is written and peer reviewed by qualified clinicians. Before Keep all medications away from children and pets. Although not all of these side effects may occur, if they do occur they may need medical attention. The .gov means its official. Accessed Sept. 7, 2022. 41% of reviewers reported a positive effect, while 50% reported a negative effect. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. You will find a full list in the manufacturer's information leaflet supplied with your medicine. People with kidney problems should be able to take the usual dose of isosorbide mononitrate (Monoket). Some products have ingredients that could worsen your heart failure. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Try to keep your regular appointments with your doctor. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Advertising revenue supports our not-for-profit mission. Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. (2) One in 3 patients never experienced headache from the given dosages. You may report side effects to the FDA at 1-800-FDA-1088. Consult your doctor before breast-feeding. It is important to take the drug at the same times each day. 46 ratings on Drugs.com. Below is the list of medicines, which contains Isosorbide Mononitrate as ingredient. The most common side-effect is headache. Yes, it's good for health but don't take it excesse in amount, use once daily for 1 month then stop it or take once a weekly. If you have recently had a head injury or a heart attack. My EKG showed Assess your symptoms online with our free symptom checker. There are a number of medications that your doctor can prescribe in place of isosorbide mononitrate (Monoket). Some conditions may become worse when the drug is suddenly stopped. Otherwise, call a poison control center right away. Ask your pharmacist for a list of the ingredients. Natural Medicines. Is isosorbide mononitrate (Monoket) the same as nitroglycerin (Nitrostat)? What are the interactions of Isosorbide Mononitrate ? Isosorbide-2,5-dinitrate and isosorbide-5-mononitrate, the low-potent organic nitrates, are directly metabolized in the endoplasmic reticulum of the vascular smooth muscle cells via cytochrome P450 enzymes, resulting in direct production of nitric oxide (Mnzel et al., 2005).In contrast, the highly potent organic nitrates such as glyceryl trinitrate (GTN) and pentaerythritile tetranitrate . Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. It is also important information to carry with you in case of emergencies. Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Overview of herbal medicines and dietary supplements. Do not stop taking it without consulting your doctor. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. you should know that you may experience headaches every day during your treatment with isosorbide. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. It works to relax your blood vessels. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Using this medicine with any of the following medicines is not recommended. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. Take extra precautions to avoid falling during your treatment with isosorbide. See also: nitroglycerin side effects in more detail. Severe postural hypotension with light-headedness and dizziness is frequently observed after the consumption of alcohol. http://www.upandaway.org. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. We comply with the HONcode standard for trustworthy health information. Do not start, stop, or change the dosage of any medicines without your doctor's approval.